Keywords: Multiple Sclerosis, Brain, MR Spectroscopic Imaging
Motivation: MR spectroscopy offers biomarkers like myo-inositol and N-acetylasparate that can better predict disability progression and clinical status in multiple sclerosis. However, traditional MR spectroscopic imaging faces challenges like limited resolution and lengthy acquisition times, hampering its clinical utility.
Goal(s): This study aimed to assess a novel 7T 3D-concentric-ring-trajectory-readout MRSI, addressing these limitations, for reliable metabolic marker imaging in MS.
Approach: Metabolic images were obtained from 26 MS patients and compared with 13 healthy controls.
Results: Altered brain metabolism in MS was effectively visualized across a large brain volume, revealing significant differences in metabolite levels within normal-appearing white matter.
Impact: We showcase extensive, high-resolution brain metabolic mapping of multiple sclerosis within a clinically viable timeframe. This can enhance disease monitoring and improve the assessment of treatment effectiveness.
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