Abstract #0268

Investigating Quantitative Perfusion Characteristics of Prostate Cancer for African American and White Men

Sohaib Naim¹, Raymi Ramirez¹, Fatemeh Zabihollahy¹, Qi Miao², Harrison Kim³, Robert E Reiter⁴, Steven Raman¹, and Kyunghyun Sung¹

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Radiology, The First Affiliated Hospital of China Medical University, Shenyang City, China, ³Radiology, University of Alabama at Birmingham, Birmingham, AL, United States, ⁴Urology, University of California, Los Angeles, CA, United States

Synopsis

Keywords: Prostate, Prostate, Health disparity, perfusion analysis

Motivation: Race and ethnicity strongly impact the risk of prostate cancer, and understanding the impact of biological heterogeneity in patients from different racial/ethnic backgrounds is crucial for reducing the observed gaps in clinical outcomes.

Goal(s): To investigate potential differences in quantitative perfusion characteristics of prostate cancer between African American and White men.

Approach: After matching commonly known clinical risk factors, the quantitative DCE-MRI analysis was performed to assess differences in perfusion parameters of the pathology- and MRI-based lesions African American and White men.

Results: Notable differences between the two cohorts were observed in the K^trans of tumors with csPCa.

Impact: Considering race-specific perfusion characteristics can help in understanding biological factors of health disparity in prostate cancer.

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