Abstract #0273

Liver T1, T2 and ADC Magnetic Resonance Fingerprinting in a single breath-hold

Carlos Velasco¹, Carlos Castillo-Passi^1,2,3, Nadia Chaher¹, Alkystis Phinikaridou¹, René M. Botnar^1,2,3,4, and Claudia Prieto^1,3,4

¹School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Millennium Institute for Intelligent Healthcare Engineering (iHEALTH), Pontificia Universidad Católica de Chile, Santiago, Chile, ⁴School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Synopsis

Keywords: MR Fingerprinting, MR Fingerprinting

Motivation: Single breath-hold simultaneous T1, T2 and ADC abdominal Magnetic Resonance Fingerprinting (MRF) in liver would allow for fast and comprehensive liver tissue characterization.

Goal(s): To develop a fast MRF sequence for T1, T2 and ADC quantification on liver tissue in a single breath-hold at 3T

Approach: Radial spoiled-GRE ~16-second acquisition with magnetization preparation modules for T1, T2 and ADC encoding was proposed, with an optimized diffusion-preparation module. Sequence was evaluated in phantoms and in 11 healthy subjects.

Results: T1, T2 and ADC quantification shows good correlation with reference maps in phantoms and good agreement in vivo against clinical scans.

Impact: Simultaneous quantification of T1, T2 and ADC in liver tissue in a single-scan is now possible with this proposed MRF sequence, allowing for a more comprehensive evaluation of hepatic disease through co-registered multiparametric imaging.

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