Keywords: Heart Failure, Modelling, Congenital Heart Disease
Motivation: The complexity of Fontan palliation in single-ventricle physiology prompts the need to understand the associated cardiovascular adaptations and their impact on ventricular function.
Goal(s): The research aims to quantify the relationship between single-ventricle contractile function and flow dynamic efficiency within the total cavopulmonary connection.
Approach: Utilizing Interventional Cardiac MR and a biomechanical heart model, this study analysed hemodynamic data from 11 post-Fontan procedure patients, correlating myocardial contractility with energy loss (EL) and clinical metrics.
Results: The analysis showed that EL significantly predicts myocardial contractility and the max(dP/dt), offering insights into the mechanical implications of Fontan circulation, with potential applications in patient-specific intervention strategies.
Impact: This study exemplifies the integration of patient-specific biomechanical modelling with clinical cardiac MRI and hemodynamic data to understand Fontan circulation, potentially providing a quantitative framework for personalized treatment strategies and improving the cardiovascular health of patients with congenital heart disease.
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