(ISMRM 2024) Interventional Cardiac MR (iCMR)-based Myocardial Mechanics and Circulatory Flow Dynamics in Patients with Fontan Circulation
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Abstract #0288

Interventional Cardiac MR (iCMR)-based Myocardial Mechanics and Circulatory Flow Dynamics in Patients with Fontan Circulation

Hamza Dahshi1, Surendranath Veeram Reddy1, Abhay Divekar1, Mohammad Tarique Hussain1, and Maria Gusseva1
1Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Heart Failure, Modelling, Congenital Heart Disease

Motivation: The complexity of Fontan palliation in single-ventricle physiology prompts the need to understand the associated cardiovascular adaptations and their impact on ventricular function.

Goal(s): The research aims to quantify the relationship between single-ventricle contractile function and flow dynamic efficiency within the total cavopulmonary connection.

Approach: Utilizing Interventional Cardiac MR and a biomechanical heart model, this study analysed hemodynamic data from 11 post-Fontan procedure patients, correlating myocardial contractility with energy loss (EL) and clinical metrics.

Results: The analysis showed that EL significantly predicts myocardial contractility and the max(dP/dt), offering insights into the mechanical implications of Fontan circulation, with potential applications in patient-specific intervention strategies.

Impact: This study exemplifies the integration of patient-specific biomechanical modelling with clinical cardiac MRI and hemodynamic data to understand Fontan circulation, potentially providing a quantitative framework for personalized treatment strategies and improving the cardiovascular health of patients with congenital heart disease.

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Keywords

flowmodelpatientscontractilitycirculationmyocardialcardiac