Abstract #0289
Trajectories of abdominal subcutaneous and visceral adipose tissue accumulation and cardiometabolic health in children: The GUSTO study
Suresh Anand Sadananthan1, Varsha Gupta1,2, Yeshe Manuel Kway1,3, Kashthuri Thirumurugan1, Mya Thway Tint1, Navin Michael1, Fabian Kok Peng Yap4,5,6, Kok Hian Tan5,7, Keith M Godfrey8, Peter D Gluckman1,9, Yap Seng Chong1,10, Dennis Wang1,11,12,13, Yung Seng Lee1,14,15, Marielle V Fortier1,16, Johan G Eriksson1,10,17,18,19, and S. Sendhil Velan1,3,17,20
1Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore, 2Bioinformatics Institute, A*STAR, Singapore, Singapore, 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4Department of Pediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, Singapore, 5Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, 6Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, 7Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore, 8MRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 9Centre for Human Evolution, Adaptation and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand, 10Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 11Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom, 12Department of Computer Science, University of Sheffield, Sheffield, United Kingdom, 13National Heart and Lung Institute, Imperial College London, London, United Kingdom, 14Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Singapore, 15Department of Paediatrics, Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, Singapore, Singapore, 16Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, Singapore, 17Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 18Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 19Folkhälsan Research Center, Helsinki, Finland, 20Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Synopsis
Keywords: Body, Body, Pediatrics, abdominal adipose tissue, subcutaneous and visceral fat, insulin resistance
Motivation: Unravel the links between childhood abdominal fat distribution patterns and subsequent cardiometabolic risks aiming to provide effective strategies for preventing childhood obesity.
Goal(s): To investigate the presence of distinct abdominal fat accumulation patterns during infancy and childhood in a multi-ethnic cohort, and their associations with cardiometabolic risk.
Approach: Latent class growth mixture modeling was used to identify three trajectories (stable, slow acceleration, rapid acceleration) for deep subcutaneous (DSAT), superficial subcutaneous (SSAT), and visceral adipose tissues (VAT).
Results: Compared to Chinese children, Indian children had higher odds of being in the rapid acceleration trajectory. All accelerated trajectories were associated with inflammatory marker, hsCRP.
Impact: This research has the potential to impact public health by providing evidence-based insights into the relationships between abdominal fat distribution patterns and cardiometabolic health. Our findings may aid development of targeted interventions and strategies to mitigate long-term adverse cardiometabolic consequences.
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