Abstract #0291

Multiorgan quantitative abdominal MRI in paediatric patients with Cystic Fibrosis

Chris R Bradley^1,2, Alex Yule^2,3, Nayan Dey^2,3, Christabella Ng^2,3, Naaventhan Palaniyappan^2,4, Zachary Peggs^1,2, Jonathan Brooke^2,4, Neele Dellschaft^1,2, Luca Marciani^1,2, Robin Spiller^2,4, Guruprasad Aithal^2,3, Caroline Hoad^1,2, Penny A Gowland^1,2, Ian Hall^2,3, Alan Smyth^2,3, Susan T Francis^1,2, and Andrew Prayle^2,3

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom, ³Population and Lifespan Sciences, University of Nottingham, Nottingham, United Kingdom, ⁴Translational Medical Sciences, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Body, Pediatric, liver, pancreas, spleen

Motivation: Cystic fibrosis (CF) is a multi-system, life-limiting genetic disorder. There is a need for multiorgan assessment in children with CF and the response to modulator therapies.

Goal(s): To perform multiorgan MRI in children to quantify lung, liver, pancreas, spleen, and gut function.

Approach: 8 children with CF and 3 healthy volunteers (HV) performed the protocol including quantitative assessment (T₁, T₂, T₂*, fat fraction (FF), stiffness) of liver, pancreas and spleen.

Results: Increased pancreas FF, T₁ and T₂, spleen T₁ and hepatic arterial velocity in CF compared to HVs. Increased liver T₁, T₂ and stiffness in a CF child independently diagnosed with liver disease.

Impact: This protocol will be used to study the effect of the Cystic Fibrosis Transmembrane Regulator Modulator therapy in children on liver toxicity, pancreas and gut function, and lung health, by performing MRI before and 12 months after commencement of Kaftrio.

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