Keywords: Hyperpolarized MR (Gas), MSK, Hyperpolarized MR (Gas), Dynamic Imaging, Pediatric, Signal Modeling, Skeletal, Preclinical, Lung, Flow, Analysis/Processing
Motivation: The pressing need to develop and evaluate novel treatments of thoracic insufficiency syndrome (TIS), a condition with significant implications for compromised pulmonary growth and function.
Goal(s): To gain deeper insights into the altered lung function associated with TIS, ultimately improving patient care and outcomes.
Approach: Dynamic hyperpolarized-xenon-129 MRI was used to assess ventilation and gas exchange dynamics in pre-clinical models of TIS.
Results: Significant ventilation and gas exchange delays were found in the TIS animals compared to the healthy ones.
Impact: Our findings hold the promise to improve TIS assessment and treatment monitoring by providing crucial insights into altered lung function. This study offers a valuable tool for clinicians/researchers, fostering improved patient care and stimulating further TIS management and intervention research.
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