Keywords: Other Neurodegeneration, Brain, Myelin plasticity; Multiparametric mapping; Magnetisation transfer; Motor learning; Quantitative MRI; Corticospinal tract; Hippocampus
Motivation: Rehabilitation following spinal cord injury is currently the only means to improve motor function. How macro-and microstructural changes in the CNS promote such recovery is understudied.
Goal(s): Investigate training-induced plasticity during motor skill training and explore associations between neuroplasticity and performance.
Approach: We compared healthy and SCI trainees and healthy non-trainees using quantitative and diffusion MRI, and associated changes in MRI parameters with performance improvement.
Results: SCI patients showed training-induced changes in cortical and subcortical areas, which were akin to those in healthy controls and were linked to specific aspects of motor skill learning.
Impact: Motor skill learning in SCI induces neuroplasticity in similar areas as seen in healthy controls. These findings open the possibility to monitor progress in neurorehabilitation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords