Abstract #0309

Characterizing iron deposits in subcortical grey matter from in vivo gradient-echo data

Rita Oliveira¹, Quentin Raynaud¹, Valerij Kiselev², Ileana Jelescu³, and Antoine Lutti¹

¹Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ²Medical Physics, Department of Radiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ³Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Gray Matter, Brain

Motivation: Transverse relaxation rate and magnetic susceptibility are MRI measures of iron concentration in subcortical grey matter. However, their relation to the microscopic distribution of iron deposits within the tissue remains elusive.

Goal(s): Our goal is to characterize the distribution of iron deposits in subcortical grey matter from in vivo gradient-echo data.

Approach: We characterize iron-rich deposits from the combination of transverse relaxation parameters of the magnitude and phase of gradient-echo data, under two limiting regimes.

Results: The estimates of iron distribution are consistent with ex vivo studies. Data suggest that an intermediate regime might be applicable in subcortical tissue.

Impact: The characterization of the microscopic distribution of iron deposits in subcortical grey matter, from in vivo gradient-echo data, brings the opportunity to study iron-related brain changes in neurodegenerative diseases with improved specificity.

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