Abstract #0311

Serial neuromelanin MRI detects progression of depigmentation over 6 months in early Parkinson’s

Yue Xing^1,2,3, Stefan Pszczolkowski^1,2,3, Tayyib Hayat^1,4, Paul Morgan^1,2,3, Jonathan Evans⁵, Chris Tench^1,2,3, and Dorothee P. Auer^1,2,3

¹School of Medicine, Mental Health & Clinical Neurosciences, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, United Kingdom, ⁴Neurology, Queen’s medial Centre, Nottingham, United Kingdom, ⁵Neurology, Queen's medical Centre, Nottingham, United Kingdom

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Neuromelanin MRI

Motivation: The potential of neuromelanin-MRI in tracking disease progression is underexplored.

Goal(s): We investigated the detectability of changes of contrast in substructures of the substantia nigra over 6 months.

Approach: We compared changes of contrast between healthy controls and subjects with early PD.

Results: Depigmentation progresses over 6 months in early PD, but not in healthy controls, advancing the use of neuromelanin-MRI as a potential marker of PD.

Impact: Our study addresses the knowledge gap of neuromelanin-MRI as a potential progression marker of early PD, which will be particularly helpful in the context of future disease-modifying trials.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.