Keywords: fMRI Analysis, fMRI, cerebral circulation time
Motivation: Cerebral circulation time (CCT) is a metric that provides insight into cerebrovascular health. However, conventional CCT measurements typically require injection of contrast agents, or demonstrate high variability.
Goal(s): We propose an improved, contrast-free method to calculate CCT by cross-correlating fMRI signals from the putamen and sagittal sinus.
Approach: n 16 healthy adult datasets (8 subjects, 2 sessions), we compared CCT estimates using the internal carotid artery (as proposed in the literature) or putamen as “arterial” references in breath-hold and resting-state data.
Results: The putamen ROI provides more reliable CCT estimates, consistent with values from bolus-tracking methods.
Impact: A modified analysis of fMRI data provides a robust method to measure cerebral circulation time on a single-subject level. This method may offer an accessible, contrast-free metric of cerebrovascular health for future application in patient populations.
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