Keywords: Functional Connectivity, Brain Connectivity, Dynamic Causal Modeling, BOLD, Neuroscience
Motivation: Task-driven BOLD signal nonlinearities in visuomotor areas have been reported both during execution and observation of tasks.
Goal(s): We aim to study how cerebral and cerebellar regions of a visuomotor network influence each other and drive nonlinear BOLD responses.
Approach: Dynamic Causal Modeling was used to estimate causal influences as effective connectivity to assess how the activity of each region modulated BOLD signal nonlinearities in a visuomotor task.
Results: Execution and observation networks showed the same fixed (0th order) effective connectivity, while BOLD signal nonlinearities were modulated in the motor planning loop during execution only and were driven by the cerebellum.
Impact: Dynamic causal modeling elucidates the central role of the cerebellum as a forward controller in regulating input-driven modulation differentially in execution and observation. These mechanisms may be affected by pathologies and could have an important role in visuomotor disability.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords