Keywords: Functional Connectivity, fMRI (task based), pattern separation; hippocampal-cortical connection; cortical-cortical connection
Motivation: Studies have extensively demonstrated roles of hippocampus and its subdivisions during pattern separation, but cortical involvement has not yet been elucidated.
Goal(s): Our goal is to evaluate whole-brain functional connectivity changes during pattern separation.
Approach: We compared cortical-hippocampus and cortical-cortical FNCs during a total of 258 correct and incorrect lure discrimination trials, using high-resolution and high-quality 7T fMRI data.
Results: Cortical-CA3DG FNCs and cortical-CA1 FNCs were significantly involved during pattern separation and completion, respectively. Around 83.35% cortical-cortical connections were with higher FNCs during lure discriminations, indicating their potential involvement during pattern separation.
Impact: Besides hippocampus and its subdivisions, cortical regions and its connections to hippocampus might be extensively involved in pattern separation process.
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