Keywords: Task/Intervention Based fMRI, fMRI (resting state), fMRI(task based), functional connectivity, neuroscience
Motivation: Despite the enormous potential inherent in rsfMRI, the neural basis underlying rsfMRI connectivity remains unclear.
Goal(s): We aim to dissect the role of the TRN inhibitory neural population in rsfMRI connectivity given its prominent role in maintaining/regulating thalamo-cortical oscillations.
Approach: We examined brain-wide activity and rsfMRI connectivity changes after optogenetically manipulating neural activity in rodent TRN.
Results: We demonstrate that somatosensory-specific TRN inhibitory networks play a role in modulating rsfMRI connectivity of sensorimotor and default mode networks.
Impact: Present studies examining neural basis of rsfMRI have primarily focused on excitatory networks. Here, we investigated the role of a major inhibitory thalamic nucleus to advance our understanding of the contributions of inhibitory inputs in regulating brain-wide rsfMRI networks.
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