Keywords: fMRI Analysis, fMRI (resting state), Connectivity gradient, Hippocampus, Development, Cognitive training
Motivation: The hippocampus-cortical connections have shown rapid developmental-changed nature during childhood and learning-adapted plasticity with skill acquirement.
Goal(s): However, little is known about the effect of development interacting with cognitive training on the hippocampal connectivity gradient during puberty.
Approach: Here we employed longitudinal dataset (191 scans from training/control groups: n = 43/45) which collected neuroimaging data of school-age children across 0/3/5-year abacus mental calculation (AMC) training stages to explore this question.
Results: By calculating connectivity gradient of hippocampus, we observed significantly development-induced gradient aggregation of hippocampus, and training promoted that effect, which were resulted from changes in functional connectivity between hippocampus with different cortices.
Impact: These findings provide novel insights into development and training effects on function specialization of hippocampus during puberty from a largescale perspective of connectivity gradient, which may be helpful for better understanding of functionally atypical trait of hippocampal disorder for clinicians.
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