Keywords: Elastography, Elastography
Motivation: The need for advanced imaging techniques to precisely localize neuronal activity, overcoming the limitations of fMRI in terms of temporal resolution and direct measurement of neural activation.
Goal(s): To determine how neural activity influences tissue stiffness by detecting viscoelastic changes associated with neuronal firing and hemodynamic responses.
Approach: Using real-time MR elastography techniques to simultaneously measure both BOLD activation and viscoelastic changes in the brain during visual stimulation at two different time scales.
Results: Distinct viscoelastic activation patterns strongly link neurovascular coupling and tissue stiffness. However, no rapid viscoelastic response related directly to the underlying neural activity was detected.
Impact: Functional real-time MR elastography is sensitive to biomechanical property changes associated with the hemodynamic response to brain stimulation providing a valuable tool to study possible effects that occur on a subsecond timescale.
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