Abstract #0360

Fast-Relaxing Sodium Fraction in Brain Tumors

Christian Jan Oliver Neelsen¹, Sebastian Regnery², Nicolas Behl³, Nina Weckesser¹, Felix Kurz¹, Jürgen Debus², Heinz-Peter Schlemmer¹, Mark Ladd⁴, Daniel Paech⁵, and Tanja Platt¹

¹German Cancer Research Center, Heidelberg, Germany, ²Heidelberg University Hospital, Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg Ion-Beam Therapy Center (HIT), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Siemens Healthineers AG, Erlangen, Germany, ⁴German Cancer Research Center, Heidelberg University, Heidelberg, Germany, ⁵German Cancer Research Center, University Hospital Bonn, Bonn, Germany

Synopsis

Keywords: Tumors (Pre-Treatment), Cancer, Sodium, Relaxometry

Motivation: Enhance the specificity of sodium (²³Na) imaging in brain tumors.

Goal(s): Distinguish intracellular and extracellular sodium distribution in glioblastoma.

Approach: We assessed the fraction of fast-relaxing sodium (F_T2*s) in 19 glioblastoma patients using a 3D radial ²³Na pulse sequence with six echoes at 7T.

Results: F_T2*s was high in normal appearing white matter resembling expected intracellular behavior, and low in necrotic regions, akin to fluid-like environments. Values for contrast-enhancing tumors and adjacent edema were in between. The differentiation between normal brain tissue and changes in glioblastoma underscores the potential of F_T2*sto improve the specificity of sodium imaging in brain tumors.

Impact: The study could facilitate the establishment of the fast-relaxing sodium fraction as a diagnostic tool in brain tumors, potentially improving specificity in sodium quantification.

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