Abstract #0362

Feasibility of 3D APT and NOE mapping using extrapolated semi-solid magnetization transfer reference fitting in brain tumors

Osamu Togao¹, Jochen Keupp², Tatsuhiro Wada³, Koji Yamashita⁴, Kazufumi Kikuchi¹, and Kousei Ishigami⁴

¹Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Philips Research, Hamburg, Germany, ³Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, ⁴Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Synopsis

Keywords: Tumors (Pre-Treatment), CEST & MT

Motivation: Currently, APT and NOE imaging with extrapolated semi-solid magnetization transfer reference (EMR) fitting has been performed with single-slice acquisition.

Goal(s): To demonstrate the feasibility of 3D APT and NOE imaging with EMR fitting using the 3D CEST sequence with CS-SENSE in patients with brain tumors.

Approach: 3D CEST imaging with CS-SENSE was adjusted to clinical scan. EMR fitting was performed on the 3D data.

Results: 3D APT and NOE mapping was feasible in all patients with brain tumors by using the 3D CEST imaging with CS-SENSE within a clinically acceptable acquisition time.

Impact: The feasibility of 3D APT and NOE mapping using 3D CEST imaging with CS-SENSE was demonstrated. Quantitative evaluation of APT and NOE on multiple slices allows for the quantitative assessment for the entire tumor area.

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