Abstract #0363

Evaluating the Clinical Utility and Diagnostic Value of High-Resolution Deuterium MRS Imaging (DMRSI) in Patients with Brain Tumor

Xiao-Hong Zhu¹, Xin Li¹, Yudu Li^2,3, Bashar Aldaraiseh⁴, Liam Chen⁴, Zhi-Pei Liang^2,5, Clark Chen⁶, Kamil Ugurbil¹, and Wei Chen¹

¹CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Deptartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Tumors (Post-Treatment), Cancer, Deuterium metabolic Imaging

Motivation: Deuterium MRS imaging (DMRSI) can detect Warburg Effect in brain tumors; however, its clinical utility and value in brain tumor diagnosis and treatment has not been investigated.

Goal(s): To perform a preliminary investigation in human patients with brain tumor.

Approach: High-resolution dynamic DMRSI (HR-DMRSI) study was conducted in brain tumor patients on a 7T clinical scanner with an oral D66-glucose administration; biospecimens taken from DMRSI positive and negative regions were analyzed and compared with the DMRSI and clinical MRI results.

Results: HR-DMRSI technology enables detection and characterization of glioma infiltration with a level of precision surpassing traditional imaging modalities.

Impact: We clearly demonstrate that 7T high-resolution dynamic deuterium (²H) MRS imaging is able to detect and characterize glioma infiltration in individual human patients with high accuracy and specificity that exceeds conventional imaging modalities available in standard clinical setting.

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