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Abstract #0367

Functional dynamic patterns of executive networks predict postoperative attentive outcome in glioma patients

Francesca Saviola1,2, Luca Zigiotto3,4, Silvio Sarubbo3,4, and Jorge Jovicich2
1Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy, 2CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy, 3Department of Neuroscience, Division of Neurosurgery, S.Chiara Hospital, APSS Trento, Trento, Italy, 4Structural and Functional Connectivity Lab, S.Chiara Hospital, APSS Trento, Trento, Italy

Synopsis

Keywords: Tumors (Post-Treatment), Brain Connectivity, Neuroscience, Tumors

Motivation: Brain surgery glioma patients frequently exhibit attentional deficit, however the prediction of its appearance is largely unknown.

Goal(s): Investigate longitudinal temporal properties of executive function to gain insights about its relationship with cognitive attentive performance in gliomas.

Approach: We used longitudinal dynamic functional connectivity analysis of executive networking to associate it with neuropsychological attentive and executive performance.

Results: Post-surgical attentive performance is strictly related to functional temporal properties of executive networks, regardless of gliomas' features. Underlying substrates of impairment in the executive domain could be explained by looking at changes in temporal persistence of highly co-activated fronto-parietal networking.

Impact: Co-activation patterns framework enables the prediction of post-operative attentional deficits by looking at pre-surgical temporal features of executive networking. We demonstrate how the dynamic nature of the brain contains crucial features to develop clinically relevant imaging markers for gliomas recovery.

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Keywords