Keywords: Neuro, fMRI (resting state), Functional Connectivity, fMRI, Sensory Processing Disorder, Sensory Over-Responsivity
Motivation: Sensory Over-Responsivity (SOR) adversely impacts over 2.5% of children, prompting a study into its neural correlates in the absence of ASD to comprehend its unique effect on brain function.
Goal(s): We test the hypothesis that SOR in non-ASD children is linked to impaired connectivity in sensory networks and alterations in higher-order, regulatory networks.
Approach: Functional brain networks are constructed and analyzed using ICA, dual regression, fractional amplitude of low-frequency fluctuations (fALFF), and regional homogeneity (ReHo).
Results: SOR children exhibit increased functional connectivity in default-mode, frontoparietal, and salience networks, alongside reduced connectivity in visual and cerebellar networks, confirming a distinctive neural profile of SOR.
Impact: This study reveals distinct functional connectivity in SOR. It establishes a basis for novel interventions and tailored medical approaches for children, with or without ASD, encouraging further investigation into the neural basis and management of sensory processing disorders.
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