Keywords: Spectroscopy, Spectroscopy, 31P MRSI, NAD+, NADH
Motivation: Nicotinamide adenine dinucleotide (NAD) is vital in cellular metabolism, existing in an oxidized (NAD+) and reduced (NADH) form. Its submillimolar concentration in the human brain makes its whole brain mapping challenging.
Goal(s): To explore the feasibility of whole-brain NAD mapping in human.
Approach: 31P MRSI data were acquired from two volunteers using a 31P 32-channel array coil at 7T. Metabolites were quantified with LCModel.
Results: 3D whole-brain NAD maps were acquired with decent SNR within 45min. The measured NAD level and NAD+/NADH ratio were stable across two subjects and aligned with previous single-voxel studies.
Impact: Our preliminary data demonstrated the feasibility of whole-brain NAD mapping in humans at 7T, which offers the potential to study regional-specific bioenergetics under different pathological conditions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords