Abstract #0486

Ultrashort echo time quantitative magnetization transfer (UTE-qMT) MRI distinguishes human diabetic bones from healthy ones

Soo Hyun Shin¹, Dina Moazamian¹, Arya Suprana^1,2, Eddie Fu^1,3, Saeed Jerban¹, Hyungseok Jang¹, Charles Ginsberg⁴, Susan V Bukata⁵, Yajun Ma¹, Eric Y. Chang^1,3, and Jiang Du^1,2,3

¹Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ²Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States, ³Radiology Service, VA San Diego Healthcare System, La Jolla, CA, United States, ⁴Department of Medicine, University of California, San Diego, La Jolla, CA, United States, ⁵Department of Orthopedic Surgery, University of California, San Diego, La Jolla, CA, United States

Synopsis

Keywords: Bone, Diabetes, Bone

Motivation: There is no standardized method to probe bone quality, a key determinant of bone fracture risk of type 2 diabetes patients.

Goal(s): We tested whether UTE quantitative MT (UTE-qMT) imaging and UTE-based water pool measurement can distinguish diabetic bones from healthy ones.

Approach: Twenty-two ex vivo human diabetic bones and 13 healthy ones were scanned with UTE-MT, proton density UTE, and inversion recovery UTE sequences to measure qMT parameters and fractions of pore and bound water pools.

Results: The proton exchange rates from UTE-qMT showed a significant decrease in diabetic bones.

Impact: The proton exchange rate measured via UTE-qMT can distinguish diabetic bones from healthy ones. UTE-qMT may provide insight into molecular-scale bone quality that explains the increased fracture risk in type 2 diabetes patients despite the increased bone mineral density.

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