Keywords: Whole Joint, Joints, UTE, ZAP, CEST
Motivation: The study addresses the need for knee injury diagnosis by advancing MRI techniques to capture both structural and biochemical tissue characteristics.
Goal(s): The goal is to develop advanced MRI biomarkers by integrating Z-spectrum/CEST with UTE techniques, improving visualization of knee structures for detection of injuries and pathologies
Approach: We used novel Z-spectrum/CEST and UTE sequences to characterize proton exchange and obtain detailed T2* mapping, aiming to reveal precise biochemical and ultrastructural knee tissue details.
Results: Findings demonstrate improved T2* mapping and proton characterization in knee tissues, suggesting potential biomarkers for early pathology identification, although further validation is necessary for clinical application.
Impact: Multiparametric imaging of macromolecular exchange and non-exchange protons using ZAP/CEST MRI and UTE imaging with tight intervals δTE offers detailed knee tissue visualization, with potential for developing precise diagnostic biomarkers.
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