Keywords: Tumors (Pre-Treatment), Brain, Glioma, Habitat imaging
Motivation: Accurate preoperative identification of isocitrate dehydrogenase (IDH) mutation is crucial for improving patients’ management in clinical practice. Intratumor heterogeneity in gliomas limits the accurate determination of IDH mutation to some extent.
Goal(s): T1-CE-derived BBB permeability and DWI-derived cell density habitat imaging may enable more precise prediction of IDH mutation by parcellating similar voxels using a clustering method.
Approach: We developed and validated imaging habitats based on T1-CE and DWI to predict IDH mutation by localized mapping of tumor heterogeneity.
Results: The damaged vascular and hypocellular imaging habitat performed best and robust to predict the IDH mutation, and was considered as the sensitive habitat.
Impact: Fully recognizing and exploiting this heterogeneity can contribute to improving the prediction accuracy of IDH mutation status, providing more precise treatment and management strategies, and ultimately improving survival and quality of life.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords