Abstract #0511

TEXTURE ANALYSIS OF CARTILAGE REPAIR TISSUE MATURATION - COMPARISON OF TWO CARTILAGE REPAIR METHODS AND CORRELATION WITH MOCART 2.0

Veronika Janacova^1,2, Vladimir Juras ¹, Pavol Szomolanyi^1,3, Diana Sitarcikova¹, Alexandra Kirner⁴, and Siegfried Trattnig^1,2,5,6

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²CD Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, ³Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁴TETEC Tissue Engineering Technologies AG, Reutlingen, Germany, ⁵Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, ⁶Institute for Clinical Molecular MRI in the Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria

Synopsis

Keywords: Cartilage, Cartilage, Repair, Tissue, Maturarion

Motivation: To monitor patients after cartilage repair surgery, non-invasive imaging techniques are needed.

Goal(s): Study aimed to monitor cartilage repair tissue for up to two years post-surgery using GLCM analysis of T₂ maps to assess tissue structure and correlate it with the morphological MOCART 2.0 score.

Approach: 37 patients underwent either matrix-associated autologous chondrocyte transplantation or microfracturing. ROI’s were drawn onto T₂ maps at three time-points. GLCM features, mean T₂ and MOCART 2.0 scores were calculated and analysed.

Results: We found correlations between GLCM features and the MOCART 2.0 score, with significant changes in texture of the repair tissue over time for transplant patients.

Impact: This study reveals a correlation between GLCM and MOCART 2.0 in autologous chondrocyte transplantation and microfracturing. Only chondrocyte transplants showed significant tissue development over time, indicating complex maturation. These findings will impact patient monitoring in clinical trials after cartilage repair.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.