Abstract #0542

A repository-integrated tool for monitoring imaging protocol compliance in a multi-centre whole-body MRI myeloma study

Sam Keaveney^1,2, Damien J McHugh^3,4, Mihaela Rata^1,2, Alina Dragan¹, Matthew Blackledge^1,2, Erica Scurr¹, Jessica M Winfield^1,2, Dow-Mu Koh^1,2, Simon J Doran^1,2, Michael Berks⁴, James PB O'Connor^2,4,5, Alexander King⁶, Winston J Rennie⁷, Suchi Gaba⁸, Priya Suresh⁹, Paul Malcolm¹⁰, Amy Davis¹¹, Anjumara Nilak¹², Aarti Shah¹³, Sanjay Gandhi¹⁴, Mauro Albrizio¹⁵, Arnold Drury¹⁶, Guy Pratt¹⁷, Gordon Cook^18,19, Sadie Roberts¹⁸, Andrew Hall¹⁸, Matthew Jenner⁶, Sarah Brown¹⁸, Martin Kaiser^20,21, Penny L Hubbard Cristinacce⁴, and Christina Messiou^1,2

¹MRI Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom, ²Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, ³Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁴Quantitative Biomedical Imaging, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom, ⁵Department of Radiology, The Christie NHS Foundation Trust, Manchester, United Kingdom, ⁶University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom, ⁷University Hospitals of Leicester NHS Trust, Leicester, United Kingdom, ⁸University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom, ⁹University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom, ¹⁰Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom, ¹¹Epsom and St. Helier University Hospitals NHS Trust, Epsom, United Kingdom, ¹²Worcestershire Acute Hospitals NHS Foundation Trust, Worcester, United Kingdom, ¹³Hampshire Hospitals NHS Foundation Trust, Basingstoke, United Kingdom, ¹⁴North Bristol NHS Trust, Bristol, United Kingdom, ¹⁵Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, ¹⁶Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, United Kingdom, ¹⁷University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ¹⁸Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom, ¹⁹Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²⁰Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom, ²¹Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Software Tools, Translational Studies, Standardisation, reproducibility, QA/QC, multi-centre studies

Motivation: Standardisation of imaging protocols in multi-centre studies is challenging, which can hamper clinical translation.

Goal(s): This study aimed to develop and demonstrate a software tool that automatically assesses imaging protocol compliance.

Approach: The tool was containerised and integrated into an imaging repository. It was applied to a dataset from a whole-body MRI (WB-MRI) myeloma study, which included 174 examinations acquired across 10 sites with scanners from three manufacturers.

Results: The software successfully identified some parameters and sites where persistent deviations occurred, although 88% of examinations were conducted according to the relevant clinical guidelines with good overall compliance to site-specific protocols.

Impact: Repository-integrated software is presented for automated monitoring of imaging protocol compliance to support standardisation in multi-centre studies and clinical translation. A multi-centre whole-body MRI study demonstrates good compliance that could have been improved further with proactive monitoring using this tool.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.