Keywords: Data Processing, Quantitative Imaging, Prostate Cancer
Motivation: The reliable evaluation of T2-weighted MRI (T2w) signal change in prostate cancer following radiotherapy (RT) is challenging due to deformations (physiological and RT-related) and scanner/protocol acquisition variability.
Goal(s): To develop an automated and reproducible methodology for quantification of T2w signal change in longitudinal studies following RT.
Approach: The methodology includes T2w image intensity harmonization and deformable registration of post-RT to pre-RT images for automated detection of prostate, peripheral zone and tumor volume.
Results: The repeatability in T2w intensity estimation improved following the automatic registration relative to manual contours; and the quantitative changes of T2w reached significance when pre- and post-RT series were compared.
Impact: The developed methodology allows to automatically detect ROIs in post-RT MRI exams, reduces data acquisition-related variation and improves imaging features’ repeatability, thereby enables the quantitative characterization of RT-induced changes in T2w.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords