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Abstract #0567

Simultaneous T1 and T2 mapping of the brain with accelerated QuantoRAGE using optimized sequence parameters and fast neural network fitting

Tâm Johan Nguyên1,2,3, Tom Hilbert4,5,6, José P. Marques7, Berk Can Açikgöz3,8,9, Roland Kreis2,3, Jessica AM Bastiaansen3,8, Tobias Kober4,5,6, and Gabriele Bonanno1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 2Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 3Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 5Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 7Donders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 8Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 9Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

Synopsis

Keywords: Quantitative Imaging, Brain, CRLB optimization, Machine Learning, Fast-Fitting, QuantoRAGE

Motivation: T1 and T2 relaxometry provide valuable information for early pathology detection but require long scan and fitting times for high-resolution whole-brain mapping.

Goal(s): To reduce acquisition and map generation times for simultaneous T1 and T2 mapping.

Approach: The proposed accelerated sequence uses two scans instead of the original four, with parameters optimized using the Cramér-Rao lower bound (CRLB). A neural network fast fitting model is employed to drastically reduce parameter quantification times.

Results: The optimized technique reduced total acquisition time from 18:20 to 9:10 minutes and fitting time from several hours to 2 min for the entire brain.

Impact: Using QuantoRAGE, simultaneous T1 and T2 relaxometry of the whole brain with high isotropic resolution can be acquired in 9 minutes with quantitative maps generated within few seconds per slice. Both aspects bring quantitative MRI closer to clinical applications.

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Abstract

Keywords