Keywords: MR Fingerprinting, Kidney, MRF; low-rank;
Motivation: Subjective qualitative T2-weighted, T1-weighted (with and without contrast) and fat suppressed images are currently used to characterize renal masses. Characterization could be improved and standardized by using objective, generalizable, quantiative criteria.
Goal(s): In this work, 2D single-breathhold, high-resolution T1/T2/T2*/PDFF mapping rosette MRF is deployed for kidney tissue characterization.
Approach: A novel MRF reconstruction is introduced to enable reduced MRF data collection time, incorporating separate low-rank models along the TE and TR domains, Hermitian symmetry via virtual coils, and a dictionary-patch based regularization.
Results: In vivo results in healthy subjects demonstrate 2D 1x1x5 mm3 T1/T2/T2*/PDFF MRF kidney mapping in a single breath-hold.
Impact: Simultaneous mapping of T1/T2/T2*/PDFF in the kidney in a single high-resolution breath-hold scan via the proposed MRF approach is feasible. This technique could bolster traditional pre-/post- contrast renal mass protocols with objective characterization methods.
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