Keywords: Microstructure, Breast
Motivation: It is imperative to noninvasively assess molecular subtypes in patients with breast cancer, as these play a vital role in guiding treatment approaches and monitoring outcomes. However, conventional apparent diffusion coefficient measurements may not reliably identify the histopathologic differences in molecular subtypes.
Goal(s): We explore the feasibility of time-dependent diffusion MRI (td-dMRI) based microstructural mapping for noninvasive identification of molecular subtypes.
Approach: The td-dMRI method was validated on breast cancer patients, and microstructural parameters were estimated and compared among molecular subtypes.
Results: The cellularity and diameter derived from td-dMRI proved effective for identifying molecular subtypes in breast cancer.
Impact: Microstructural mapping derived from td-dMRI proves to be an effective method for predicting molecular subtypes, demonstrating unique microstructural properties acroess various molecular subtypes, and thus is promising in personalizing treatment strategies.
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