Abstract #0598

Tensor-Valued Diffusion MRI Identifies Brain Microstructural Alterations in Gene Knockdown Mouse

Jianyu Yuan^1,2, Yuxuan Liu^1,2, Shuai Li^1,2, Mingyao Liang^1,2, Yi He^1,2, Huanhuan He^1,2, and Hong Shan^1,2

¹The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China, ²Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China

Synopsis

Keywords: Microstructure, Brain Connectivity, Tensor-Valued Diffusion MRI, Microscopic anisotropy kurtosis (MKA) , Genetic diseases

Motivation: DEAD‐box helicase 24 (DDX24) gene mutations linked to abnormalities of major vessels¹. However, the effect of the gene DDX24 on brain microstructure remains unclear.

Goal(s): Our goal was to demonstrate how advanced tensor-valued diffusion MRI can reveal microstructural alterations in a Ddx24 knockdown mouse model.

Approach: We performed advanced tensor-valued diffusion MRI to examine Ddx24 knockdown mouse brain and evaluated the performance of Ddx24 knockdown mice in the Morris water maze test.

Results: Ddx24 knockdown mouse revealed declining microscopic anisotropy kurtosis (MK_A) in corpus callosum and hippocampus. Tensor-valued diffusion MRI is a sensitive neuroimaging tool to evaluate gene-edited mouse brain microstructural alterations.

Impact: Advanced tensor-valued diffusion MRI provided cylinders shapes sensitive MK_A and spherical shapes sensitive MKI for detecting microstructural alterations in genetic diseases.

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