Keywords: Simulation/Validation, Simulations
Motivation: Can two different diffusion experiments (tensor-valued encoding and oscillating-gradient-spin-echo) support the role of axon beading for diffusion restriction in acute ischemic stroke?
Goal(s): To evaluate whether tensor-valued diffusion encoding yields an axon beading model that predicts experimental ischemic changes of diffusivity measured with OGSE.
Approach: Tensor-valued and OGSE/PGSE diffusion MRI were measured in the same acute stroke patients. Monte Carlo simulations were used to assess the links between these two independent measurements.
Results: The tensor-valued derived beading model predictions were in general agreement with independent experiments of less diffusivity reduction with OGSE than PGSE within stroke lesions.
Impact: Novel diffusion MRI sequences such as tensor-valued encoding and oscillating-gradient-spin-echo are complementary methods that point to the same microstructural basis (i.e. beading and elevated intra-cellular volume fraction) for the clinically useful diffusion reduction in acute ischemic stroke.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords