Keywords: Heart Failure, Heart, Cardiovascular; Acquisition Methods; Analysis/Processing
Motivation: Routine cardiac function assessment uses breath-held 2D cine imaging. Self-gated free-running sequences have recently been proposed to simplify the workflow. However, at 3T, GRE-based sequences require contrast agents to achieve blood-myocardium contrast.
Goal(s): This study introduced a contrast-agent-free acquisition for assessing cardiac anatomy and function at 3T.
Approach: Based on an interrupted free-running sequence, the proposed approach integrates T2 preparation and recovery modules to optimize blood-to-myocardium-contrast. A compressed-sensing-based reconstruction was used to generate 5D images of the whole heart.
Results: The framework was validated in 11 healthy volunteers, where it demonstrated slightly lower contrast but enabled effective left-ventricle segmentation and exhibited high reproducibility.
Impact: The proposed study introduces a contrast-agent-free method for a comprehensive 5D assessment of cardiac anatomy and function at 3T in a 5-minute acquisition. Demonstrating high agreement with the routine method, this approach holds promise for enhancing the overall patient management.
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