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Abstract #0629

Time-Resolved Cardiac function: Myocardium Strain and First-Pass Perfusion Using MR-MOTUS

Thomas E. Olausson1,2, Maarten L. Terpstra1,2, Niek R.F. Huttinga1,2, Casper Beijst2, Niels Blanken3, Dominika Suchá3, Teresa Correia4,5, Cornelis A.T. van den Berg1,2, and Alessandro Sbrizzi1,2
1Computational Imaging Group for MR Therapy and Diagnostics, University Medical Center Utrecht, Utrecht, Netherlands, 2UMC Utrecht Cancer Center, Department of Radiotherapy, University Medical Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Radiology, University Medical Centre Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, 4School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 5Centre for Marine Sciences (CCMAR), Faro, Portugal

Synopsis

Keywords: Myocardium, Image Reconstruction, First-Pass Myocardial Perfusion; Motion estimation; Motion correction; Low-Rank & Sparse; Time-resolved imaging; Cine; Dynamic; Perfusion; Cardiac

Motivation: We aim at improving accuracy and reliability in cardiac imaging for coronary artery disease diagnosis and management. We address motion artifacts in first-pass myocardial perfusion MR imaging.

Goal(s): To develop and validate motion correction techniques for motion field accuracy and strain quantification in non-ECG triggered myocardial first pass perfusion examinations.

Approach: We use a modified MR-MOTUS framework for motion separation and reconstruction in patient data.

Results: Our approach demonstrates higher accuracy in respiratory/cardiac motion field estimation with additional strain analysis.

Impact: Our findings have the potential to improve patient care by enabling free-breathing and non-ECG triggered examinations of myocardial first-pass perfusion simultaneously with strain analysis. We also open avenues for further research in cardiac imaging and motion correction techniques.

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Keywords