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Abstract #0637

Quantitative UTE Imaging of Zonal Difference in Meniscus

Arya Suprana1,2, Melissa Lou Silva2, Marco Toto-Brocchi2, Bhavsimran Malhi2, Jiyo Athertya2, James Lo1,2, Soo Hyun Shin2, Nicole Le1,3, Eric Y Chang2,3, Jiang Du1,2,3, and Yajun Ma2
1Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, San Diego, CA, United States, 2Department of Radiology, University of California, San Diego, San Diego, CA, United States, 3Radiology Service, Veterans Affairs San Diego Health Care System, San Diego, CA, United States

Synopsis

Keywords: Quantitative Imaging, Cartilage, Meniscus

Motivation: Quantitative MR imaging techniques could reveal compositional differences between red and white zones in menisci. Unfortunately, this type of analysis may not be possible using conventional sequences due to the rapid signal decay of menisci.

Goal(s): The study aimed to investigate whether quantitative UTE imaging techniques could detect the zonal difference between the red and white zones in menisci.

Approach: UTE imaging techniques, including UTE-T1, UTE-MT modeling, UTE-AdiabT1ρ, and UTE-T2*, were used to assess menisci in vivo quantitatively.

Results: T1, MMF, and T2* values in the red zone are significantly lower than those in the white zone.

Impact: Our qUTE MRI techniques enable a quantitative, zonal, and compositional analysis of menisci in vivo, which is valuable in helping understand the role of menisci in the pathogenesis of complex diseases such as osteoarthritis.

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Keywords