Keywords: Dementia, Alzheimer's Disease, Biomarker's, Novel contrast mechanisms
Motivation: Magnetic resonance elastography (MRE) is typically used to assess shear mechanical properties of a tissue. A new measure related to the compressibility of a tissue could provide new insights into disease processes.
Goal(s): To test a new measure related to the tissue compressibility in application to neurological disorders.
Approach: A measure of compressibility was defined as the ratio of the magnitude of the divergence over the magnitude of the curl of displacements.
Results: Normal pressure hydrocephalus and Alzheimer’s disease displayed distinct patterns of compressibility measure compared to the control group.
Impact: An MRE-based compressibility measure demonstrates unique patterns in normal pressure hydrocephalus and Alzheimer’s disease. This may provide new insights into disease processes and guides future research.
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