Keywords: New Devices, New Devices
Motivation: The absence of hardware specifically tailored for horizontal bore small animal MRI systems hinders the achievement of ultrahigh-resolution imaging.
Goal(s): To facilitate volumetric imaging at sub 10³ µm³ spatial resolutions in a conventional horizontal small animal scanner.
Approach: A custom-made high-performance gradient system and RF-hardware was interfaced to the system RF- and gradient-amplifiers, avoiding the requirement for specialized imaging software. A constant time imaging sequence was employed to capture ultrahigh-resolution images.
Results: The setup was successfully tested for imaging of zebrafish embryos at different time points post fertilization with an isotropic spatial resolution of 9³ µm³.
Impact: The suggested approach enables isotropic single-digit µm ultrahigh resolution imaging in conventional horizontal bore MRI systems. This supports novel imaging applications for a wide range of tiny animals, plants, or biological tissue without dedicated microscopy MR systems.
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