Keywords: Biology, Models, Methods, Diffusion/other diffusion imaging techniques, inflammation, brain, degeneration, demyelination
Motivation: Validation of MRI-extracted biomarkers is seldom performed, and when available,
Is normally underpowered and based on correlation.
Goal(s): Here we present an innovative framework for validating microstructural MRI biomarkers by eliciting cell-specific responses.
Approach: The framework is based on injection of neurotoxins in rats, followed by MRI exploration and histology.
Results: We successfully isolated conditions associated to neurodegenerative, demyelinating and inflammatory pathologies and demonstrated sensitivity and specificity of MRI- derived biomarkers.
Impact: This framework impulse a much-needed change in paradigm for MRI validation by challenging the biological content of MRI derived biomarkers, refine and test new models for microstructural imaging and bridge the gap between advances in MRI physics and clinical applications.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords