Meeting Banner
Abstract #0695

Sex- and brain region-specific 1H MRS neurometabolic profiles in young rats with hepatic encephalopathy

Jessie Mosso1,2, Katarzyna Pierzchala1,2, Dario Sessa1,2, Stefanita Mitrea1,2, Estelle Gerossier1,2, Brayan Alves1,2, Olivier Braissant3, Valérie A. McLin4, and Cristina Cudalbu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Service of Clinical Chemistry, University of Lausanne and University Hospital of Lausanne, Lausanne, Switzerland, 4Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva and University of Geneva Medical School, Geneva, Switzerland

Synopsis

Keywords: Spectroscopy, Metabolism, MRS, hepatic encephalopathy, sex-difference, SPECIAL

Motivation: The lack of preclinical studies on potential sex-differences in the pathophysiology of hepatic encephalopathy (HE) prevents a comprehensive understanding of the disease.

Goal(s): To study the effect of sex on the neurometabolic profiles measured with 1H MRS.

Approach: We compared 1H MRS metabolite concentrations in the hippocampus and striatum of young male versus female rats with HE.

Results: We observed overall stronger neurometabolic effects of the disease on male versus female HE rats, including weight loss and decrease in brain antioxydants levels (Asc, GSH), likely hampering the capacity of male animals to counteract oxidative stress, important player in the pathophysiology of HE.

Impact: Sex-differences, often overlooked in preclinical studies, investigated here showed distinct 1H MRS neurometabolic profiles in female versus male rats with hepatic encephalopathy (HE), opening a new window of investigation for patients with HE.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords