Abstract #0705

Assessment of rhabdomyolysis-induced acute kidney injury with chemical exchange saturation transfer MRI

Qianqian Zhang^1,2, Quan Tao^2,3, Zelong Chen⁴, Erdmann Seeliger⁵, Kan Deng⁶, Zhigang Wu⁷, Thoralf Niendorf⁸, and Yanqiu Feng^1,2

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, ³Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ⁴Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁵Institute of Translational Physiology, Charite-Universitatsmedizin Berlin, Berlin, Germany, ⁶Philips Healthcare, Guangzhou, China, ⁷Philips Healthcare, Shenzhen, China, ⁸Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbruck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Synopsis

Keywords: Small Animals, CEST & MT

Motivation: There is a gap in exploring the progression of acute kidney injury (AKI) caused by rhabdomyolysis (RM).

Goal(s): Investigate the feasibility of CEST MRI for assessing the progression of RM-induced AKI in a mouse model.

Approach: The RM-AKI model was established by intramuscular injection of glycerol solution and examined longitudinally by CEST (days 1, 3, 7, 15, 30). CEST quantification parameters and their diagnostic performance were compared.

Results: MTR presented a significant difference, and showed the best diagnostic performance for AKI and moderate negative correlations with pathological changes.

Impact: MTR has potential clinical utility for assessing renal diseases.

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