Keywords: Epilepsy, Neuroinflammation, anti-NMDAR, Spectroscopy, rCBV
Motivation: The chronic phase of autoimmune encephalitis includes persistent loss of cognitive and adaptive functions leading to long-term disability. MR-based modalities help in longitudinal studies to understand disease progression and response to treatment.
Goal(s): To investigate the in vivo MRI-based methods sensitive to detecting the alterations in metabolites and perfusion in encephalitis patients.
Approach: 1H-MRS and rCBV were performed on encephalitis patients with memory deficits and healthy controls.
Results: Changes in metabolite concentrations in the hippocampus and cortex suggest the long-term effect of neuroinflammation in patients. Reduced hippocampal rCBV in memory deficit patients is consistent with clinical cognitive assessments.
Impact: Altered brain metabolite concentrations and regional blood volume were detected with 1H-MRS and rCBV in autoimmune encephalitis and memory deficit patients. This approach can support the investigation of the role of angiogenesis and neurogenesis in memory loss in chronic encephalitis.
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