Keywords: Infectious Disease, Brain Connectivity, fMRI (task-based), High-Field MRI
Motivation: To assess Functional Connectivity (FC) differences between healthy individuals and Myalgic Encephalomyelitis or chronic fatigue syndrome (ME/CFS) patients using ultra-high-field fMRI.
Goal(s): Are there significant FC differences between brainstem and cerebellum regions comparing ME/CFS and healthy controls? Is there any association between clinical measures and FC in ME/CFS?
Approach: fMRI data were acquired on 7Tesla scanner during cognitive Stroop color-word task. Using a-priori regions, FC was assessed in CONN toolbox.
Results: Weaker FC was observed between brainstem and cerebellum regions along with altered FC within the intrinsic network hubs which supports our hypothesis of connectivities being defective in ME/CFS within those regions.
Impact: FC analyses using ultra-high-field MRI facilitates our understanding of the underlying patho-mechanisms of the cognitive deficits in ME/CFS and their progression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords