Abstract #0759

Alterations in superficial white matter tracts are associated with pathological deposition in early-stage Alzheimer’s disease

Shuyue Wang¹, Fan Zhang², Qingze Zeng¹, Hui Hong¹, Yeerfan Jiaken¹, Xinfeng Yu¹, Xiao Luo¹, Kaicheng Li¹, Xiaopei Xu¹, Peiyu Huang¹, Jianzhong Sun¹, Minming Zhang¹, and Lauren J. O’Donnell³

¹The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²University of Electronic Science and Technology of China, Chengdu, China, ³Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Alzheimer's Disease, Brain, diffusion magnetic resonance imaging, superficial white matter

Motivation: Between-cortical connections largely depend on the superficial white matter (SWM) fibers, which are less studied in the AD continuum.

Goal(s): To determine the relationship between superficial white matter (SWM) fiber microstructure and local pathology, and the SWM's impact on cognition.

Approach: We defined cohort groups in the early AD continuum. We quantified the microstructure of SWM fiber tracts (diffusion MRI) and the regional pathological deposition (PET). We analyzed associations between SWM fiber microstructure and regional pathologies in cortical areas connected by the tract.

Results: SWM tract microstructure is affected by pathology in the cortical regions connected by the tract, and this affects memory.

Impact: We localize pathology-affected SWM connections, assess their roles in cognition, and provide new insights into white matter abnormalities in the AD continuum.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.