Abstract #0771

Bone Metabolic-Morphologic relation is Mediated by Gait; Cartilage Compositional-Morphologic relation isn’t: PET/MRI in Isolated PFJOA

Rupsa Bhattacharjee¹, Eric Hammond², Chotigar Ngarmsrikam¹, Fei Jiang³, Misung Han¹, Richard B Souza^1,2, Valentina Pedoia^1,4, and Sharmila Majumdar¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, CA, United States, ²Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco (UCSF), San Francisco, CA, United States, ³3. Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF), San Francisco, CA, United States, ⁴Altos Labs, San Francisco, CA, United States

Synopsis

Keywords: Cartilage, PET/MR

Motivation: Whether the compositional, metabolic, and biomechanical relationships have a mediated effect on one another is the next crucial step toward decoding the isolated PFJOA mechanism.

Goal(s): To investigate whether the relationship of morphological-joint-degradation with SUV-values from ¹⁸NaF-PET and cartilage-T₂ in isolated-PFJOA are mediated by gait-biomechanics.

Approach: Linear regression was performed between (i)WORMS_BME(predictor) vs. Medial-SUV_max, Lateral-SUV_max (outcomes), and (ii) WORMS_Cartilage(predictor) vs. Mean-T_{2-Deep-Medial}, T_{2-Superficial-Medial}, T_{2-Deep-Lateral}, T_{2-Superficial-Lateral} (outcomes) patellar and trochlear. For significant correlations, mediation analyses were done to examine the role of Normalized-Mean-Peak vGRF_IP as a mediator.

Results: WORMS_BME vs. Medial-SUV_max, Lateral-SUV_maxrelationships are mediated by gait; WORMS_Cartilage vs. Mean-T_{2-Deep-Medial}, T_{2-Superficial-Medial}, T_{2-Deep-Lateral}, T_{2-Superficial-Lateral}aren’t mediated.

Impact: This is the first step towards understanding the flow of causalities and mediated interrelationships of bone remodeling (SUV), morphological degradation (WORMS), cartilage loss (T₂), and gait biomechanics in a complex joint developing isolated PFJOA

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