Keywords: Kidney, Kidney
Motivation: T2-based method was recently extended to measure renal oxygen metabolism. However, MLEV T2-preparation can be less robust due to field inhomogeneity in abdomen.
Goal(s): The goal is to propose a field-insensitive method for renal oxygenation quantification.
Approach: An adiabetic T2-preparation (BIR-n) method was proposed. Simulation and phantom studies was performed to demonstrate the field-insensitivity. In-vivo experiements were conducted to examine the test-retest reproducibility.
Results: A robust T2 quantification at different B0 and B1 offsets were demonstrated. In-vivo experiments showed a good test-retest reproducibility. Oxygenation was also found to be consistent between left and right renal veins, and showed significant correlation with blood flow.
Impact: The proposed method has the potential to provide accurate and stable estimation of renal oxygen extraction and metabolism in a number of renal diseases.
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