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Abstract #0784

Repeatability of DTI and tractography biomarkers in healthy kidneys

Joao Periquito1, Kanishka Sharma1,2, Kywe Soe1, Bashair Alhummiany3, Jonathan Fulford4, David Shelley3, Mark Gilchrist4, Kim Gooding4, Angela Shore4, Maria Gomez5, and Steven Sourbron1
1The University of Sheffield, Sheffield, United Kingdom, 2Antaros Medical AB, Mölndal, Sweden, 3Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 4University of Exeter Medical School, Exeter, United Kingdom, 5Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

Synopsis

Keywords: Kidney, Kidney

Motivation: For clinical application uncertainty of DTI and tractography biomarkers is critical to avoid that management decisions are made based on changes that are due to measurement error.

Goal(s): Provide a comprehensive reference guide of estimated uncertainties for DTI and tractography renal biomarkers and use the data to screen these biomarkers based measurement precision.

Approach: Five healthy-volunteers were scanned 4 times on 3T MRI scanner using a diffusion free-breathing protocol. DTI and tractography parameters were calculated using DIPY.

Results: Tractography markers are less precise than DTI, sphericity is the most reliable of all DTI metrics, and histogram metrics kurtosis and skewness are inherently imprecise.

Impact: This study presents comprehensive reference values for error ranges in renal DTI that will help to identify real (patho)physiological changes in future clinical results

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