Abstract #0801

Brain Clearance Assessment Using the DTI-ALPS Index and Intrathecal Contrast Enhanced Magnetic Resonance Imaging

Ingrid Mossige^1,2, Tryggve Holck Storås¹, Kyrre Eeg Emblem¹, Per Kristian Eide^2,3, and Geir André Ringstad⁴

¹Division of Radiology and Nuclear Medicine, Department of Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway, ²Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, ³Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, Norway, ⁴Department of Radiology, Oslo University Hospital-Rikshospitalet, Oslo, Norway

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: To investigate if DTI-ALPS as a non-invasive method compared to intrathecal contrast enhanced magnetic resonance (gMRI) imaging can be used for evaluating human brain clearance function.

Goal(s): To investigate whether or not DTI-ALPS can be used as a non-invasive alternative to gMRI.

Approach: This study compared the ALPS index with brain clearance parameters derived from gMRI in a reference group (REF).

Results: No significant relationships were found between the ALPS index and change in normalized T1w signal intensity from the gMRI data in both the distribution phase and clearance phase.

Impact: The proposed DTI-ALPS index may not be a valid marker of glymphatic function.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.