Abstract #0802

Locus Coeruleus Influence on Cognitive Function via the Glymphatic System in Parkinson's Disease

Xinhui Wang¹, Ewart Mark Haacke^2,3, Naying He⁴, Yu Liu⁴, Peng Wu⁵, and Fuhua Yan^3,6

¹Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Wayne State University, Detroit, MI, United States, ³Radiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵Philips Healthcare, Shanghai, China, ⁶College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: The underlying mechanism of locus coeruleus (LC) in cognitive function of Parkinson’s disease (PD) has not been clearly elucidated.

Goal(s): To investigate the relationship among LC degeneration, cognitive function, and the glymphatic system in PD.

Approach: All participants underwent neuromelanin-sensitive magnetic resonance imaging (NM-MRI) and diffusion tensor image scanning. The whole brain glymphatic activity was measured using diffusion along the perivascular space (ALPS) index, while LC degeneration was estimated using the NM contrast-to-noise ratio of LC (CNR_LC).

Results: Mediation analysis demonstrated that the ALPS index acted as a significant mediator between CNR_LC and the MoCA score in PD subjects.

Impact: These findings enhance our grasp of how the LC noradrenergic system influences cognitive function through the glymphatic system. This research offers a promising starting point for exploring potential therapies and further research into cognitive impairment in Parkinson's disease.

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