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Abstract #0820

Prenatal fat-water MRI-based body composition reference charts and sexual dimorphism

Aviad Rabinowich1,2,3, Netanell Avisdris3,4, Bossmat Yehuda3,5, Ayala Zilberman2,6, Bar Neeman1,2, Tamir Graziani1,2, Jayan Khawaja1,2, Sharon Vanetik Klein2,7, Bella Specktor-Fadida8, Jacky Herzlich2,9, Leo Joskowicz8,10, Liat Ben Sira1,2, Liran Hiersch2,6, and Dafna Ben Bashat2,11,12
1Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Sagol Brain Institute, Tel Aviv Soursaky Medical Center, Tel Aviv, Israel, 4The Hebrew University of Jerusalem, Jerusalem, Israel, 5Sagol school of neuroscience, Tel Aviv University, Tel Aviv, Israel, 6Department of Obstetrics and Gynecology, Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 8School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, 9Neonatal Intensive Care Unit, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 10Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel, 11Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 12Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Synopsis

Keywords: Fetal, Fetus

Motivation: Preterm infants’ nutritional management should aim to replicate the intrauterine body composition. However, intrauterine body composition reference charts are lacking.

Goal(s): We aimed to construct MRI-based intrauterine body mass (BM), fat mass (FM), percent FM (%FM), fat-free mass (FFM), and percent FFM (%FFM) body composition reference charts.

Approach: Fetal body composition was computed from T2-weighted and fat-water images. Body and subcutaneous fat volumes were automatically segmented using neural networks, and BM, FM, %FM, FFM, and %FFM were calculated.

Results: Data of 176 participants with apparently normal singleton fetuses were included. All parameters significantly changed throughout gestation, and differences between sexes were seen.

Impact: MRI-based intrauterine BM, FM and FFM body composition reference charts may be used as reference for appropriate prenatal growth and may assist in nutritional management of preterm infants.

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Abstract

Keywords